A LINE element from the pufferfish (fugu) Fugu rubripes which shows similarity to the CR1 family of non-LTR retrotransposons

Gene. 1999 Feb 18;227(2):169-79. doi: 10.1016/s0378-1119(98)00600-3.

Abstract

This study describes the consensus sequence of a full-length (4585bp) non-LTR retrotransposon from the fugu fish, Fugu rubripes. The retrotransposon, termed Maui, is represented by a group of very similar LINE elements found as multiple copies within the fish genome. Two long open reading frames (ORFs) are predicted from the sequence. The first ORF has a domain resembling a novel zinc finger motif recently found in both a turtle and a chicken (CR1) non-LTR retrotransposon. The second ORF includes sequences homologous to the endonuclease, reverse transcriptase and carboxy-terminal domains found in other non-LTR retrotransposons. Sequence comparisons of the predicted translation products of the two ORFs indicate that Maui is most closely related to a class of non-LTR retrotransposons represented by the CR1-like elements (chicken repeat 1 elements) that are present in several avian species and have recently been described in the turtle Platemys spixii. The sequence of the 3' untranslated region also supports this relationship since Maui resembles the CR1 like elements in not having a poly-A tail.

MeSH terms

  • 3' Untranslated Regions / genetics
  • 5' Untranslated Regions / genetics
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Fish Proteins*
  • Fishes / genetics*
  • Gene Dosage
  • Long Interspersed Nucleotide Elements / genetics*
  • Molecular Sequence Data
  • Open Reading Frames
  • Phylogeny
  • Polymerase Chain Reaction
  • Proteins / genetics*
  • Retroelements / genetics*
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Zinc Fingers / genetics*

Substances

  • 3' Untranslated Regions
  • 5' Untranslated Regions
  • Fish Proteins
  • Maui protein, Fugu rubripes
  • Proteins
  • Retroelements

Associated data

  • GENBANK/AF086712