This article provides an overview of the technique of magnetic resonance venography (MRV) and its relative value in the diagnostic work-up of suspected lower or upper extremity venous thrombosis. MRV is accurate for diagnosis or exclusion of deep vein thrombosis. MRV should be considered complimentary, in many instances, to the less expensive modality of venous sonography. It is the complimentary use of magnetic resonance techniques at the level of the pelvis and the mediastinum that offers the greatest cost benefit as part of an incremental strategy for the work-up of patients presenting with lower or upper extremity swelling.