Positional isomers of acetaminophen differentially induce proliferation of cultured breast cancer cells

Toxicol Lett. 1999 Jan 11;104(1-2):11-8. doi: 10.1016/s0378-4274(98)00227-6.

Abstract

This study demonstrates that acetaminophen (p-acetamidophenol) stimulates proliferation of estrogen-responsive cultured breast cancer cells and assesses if the proliferative activity of p-acetamidophenol is influenced by the -OH moiety position on the benzene ring. The effects of p-, m-, and o-acetamidophenol on cell number and on percentage cells in S phase of the cell cycle were determined for two estrogen receptor positive, human breast cancer cell lines, T47D and MCF7. Therapeutic concentrations of p-acetamidophenol (0.1 mM) significantly increased breast cancer cell proliferation. The relative order of potency of isomers in stimulating proliferation in both cell types was p- > m- > o-acetamidophenol, indicating the -OH position on the benzene ring influences the proliferation output in cultured breast cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetaminophen / chemistry
  • Acetaminophen / toxicity*
  • Analgesics, Non-Narcotic / chemistry
  • Analgesics, Non-Narcotic / toxicity*
  • Breast Neoplasms / pathology*
  • Cell Cycle / drug effects
  • Cell Division / drug effects
  • Chromatography, High Pressure Liquid
  • Estradiol / pharmacology
  • Female
  • Humans
  • Isomerism
  • Neoplasms, Hormone-Dependent / pathology*
  • Spectrophotometry, Ultraviolet
  • Tumor Cells, Cultured

Substances

  • Analgesics, Non-Narcotic
  • Acetaminophen
  • Estradiol