Mice or rats were pretreated P. O. with 8.0 gg.kg-1, 15.0 g.kg-1 and 30.03 g.kg-1 of Jiangtang Oral Solution once daily for 10 days respectively. The results showed that Jiangtang Oral Solution did not affect the glycemia and lipid in normal mice and rats, but significantly lowered the blood sugar in hyperglycemic mice and rats induced by alloxan, adrenalin, and streptozotocin. Meanwhile, Jiangtang Oral Solution significantly lowered blood lipid in mice and rats induced by yolk and high cholesterol foods. This study provides a reliable pharmacologic base for the clincal use of Jiangtang Oral Solution.