The controversial M cell

J Cardiovasc Electrophysiol. 1999 Feb;10(2):244-60. doi: 10.1111/j.1540-8167.1999.tb00667.x.

Abstract

A recent publication by us has been interpreted by some as arguing against the existence and importance of M cells. We suppose this is the reason we have been asked to write this "controversy." Regrettably for the controversy, neither our work nor we deny the existence of M cells. Rather, we have confirmed, conceivably ad nauseum, that M cells do exist and contribute importantly to the expression of electrical activity in the intact myocardium. What controversy there is relates to (1) whether there is an inhomogeneous transmural gradient for ventricular repolarization in normal hearts, and (2) why the electrophysiologic properties of different myocardial sites differ so markedly at the level of the isolated tissue and single cell and yet become so much more homogenous in the intact ventricle. These issues are addressed on the following pages.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Action Potentials / drug effects
  • Action Potentials / physiology
  • Animals
  • Anti-Arrhythmia Agents / pharmacology
  • Endocardium / cytology
  • Endocardium / drug effects
  • Endocardium / physiology
  • Heart Ventricles / cytology
  • Heart Ventricles / drug effects
  • Humans
  • Membrane Potentials
  • Myocardium / cytology*
  • Myocardium / metabolism
  • Neurotransmitter Agents / pharmacology
  • Pericardium / cytology
  • Pericardium / drug effects
  • Pericardium / physiology
  • Ventricular Function*

Substances

  • Anti-Arrhythmia Agents
  • Neurotransmitter Agents