Structure elucidation of fungal beauveriolide III, a novel inhibitor of lipid droplet formation in mouse macrophages

I Namatame; H Tomoda; N Tabata; S Si; S Omura

doi:10.7164/antibiotics.52.7

Structure elucidation of fungal beauveriolide III, a novel inhibitor of lipid droplet formation in mouse macrophages

J Antibiot (Tokyo). 1999 Jan;52(1):7-12. doi: 10.7164/antibiotics.52.7.

Authors

I Namatame¹, H Tomoda, N Tabata, S Si, S Omura

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Kitasato University, and Research Center for Biological Function, The Kitasato Institute, Tokyo, Japan.

PMID: 10092190
DOI: 10.7164/antibiotics.52.7

Abstract

The structure of fungal beauveriolide III, an inhibitor of lipid droplet formation in mouse macrophages, was elucidated to be cyclo-[(3S,4S)-3-hydroxy-4-methyloctanoyl-L-phenylalanyl-L-alanyl- D-allo-isoleucyl] by spectral analyses and chemical degradation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chromatography, High Pressure Liquid
Depsipeptides*
Hydrolysis
Lipid Metabolism
Macrophages, Peritoneal / drug effects
Macrophages, Peritoneal / metabolism
Magnetic Resonance Spectroscopy
Mice
Peptides, Cyclic / chemistry*
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Stereoisomerism

Substances

Depsipeptides
Peptides, Cyclic
beauverolides