Carcinosarcoma, endometrial intraepithelial carcinoma and endometriosis after tamoxifen therapy in breast cancer

Eur J Obstet Gynecol Reprod Biol. 1999 Jan;82(1):85-7. doi: 10.1016/s0301-2115(98)00166-3.

Abstract

The fourth case of heterologous mesodermal tumour of the uterine corpus, that developed, years following tamoxifen therapy for breast cancer in a postmenopausal woman with no previous pelvic irradiation, is presented with coincidental endometriosis and endometrial intraepithelial carcinoma. This coincidence after tamoxifen treatment appears to be an indication for the possible carcinogenic potency of tamoxifen.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents, Hormonal / adverse effects*
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / pathology
  • Carcinoembryonic Antigen
  • Carcinoma in Situ / chemically induced*
  • Carcinosarcoma / chemically induced*
  • Endometriosis / chemically induced*
  • Fatal Outcome
  • Female
  • Humans
  • Mixed Tumor, Mullerian / chemically induced*
  • Mixed Tumor, Mullerian / pathology
  • Mixed Tumor, Mullerian / therapy
  • Receptors, Estrogen / analysis
  • Tamoxifen / adverse effects*
  • Tomography, X-Ray Computed
  • Uterine Neoplasms / chemically induced*
  • Uterine Neoplasms / pathology
  • Uterine Neoplasms / therapy

Substances

  • Antineoplastic Agents, Hormonal
  • Carcinoembryonic Antigen
  • Receptors, Estrogen
  • Tamoxifen