The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity

Scand J Immunol. 1999 Apr;49(4):362-6. doi: 10.1046/j.1365-3083.1999.00522.x.

Abstract

The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-gamma response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated with a stronger inflammatory response, resulting in large granulomatous structures and eventual tissue damage.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Inhalation
  • Aerosols
  • Animals
  • Cytokines / biosynthesis
  • Disease Models, Animal
  • Female
  • Granuloma, Respiratory Tract / etiology
  • Granuloma, Respiratory Tract / immunology
  • Granuloma, Respiratory Tract / pathology
  • Injections, Intravenous
  • Lung / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Mycobacterium tuberculosis / pathogenicity*
  • RNA, Messenger / biosynthesis
  • Tuberculosis, Pulmonary / etiology*
  • Tuberculosis, Pulmonary / immunology*
  • Tuberculosis, Pulmonary / pathology

Substances

  • Aerosols
  • Cytokines
  • RNA, Messenger