[Effective treatment combining antithymocyte globulin, cyclosporin A, and granulocyte colony-stimulating factor for atypical paroxysmal nocturnal hemoglobinuria accompanied by bone marrow hypoplasia]

Rinsho Ketsueki. 1999 Mar;40(3):240-3.
[Article in Japanese]

Abstract

A 25-year-old man was admitted for evaluation of pancytopenia on May 2, 1997. On admission, he had pancytopenia with a normal reticulocyte count. Bone marrow aspirate specimens displayed a normal karyotype and hypocellularity without myelodysplasia. Although total bilirubin and lactate dehydrogenase levels were within their normal ranges, the haptoglobin level was low; additionally, two-color flow cytometric analysis determined that 3.3% of erythrocytes were double-negative for CD55 and CD59 expression. Atypical paroxysmal nocturnal hemoglobinuria with bone marrow hypoplasia was diagnosed. Because initial treatment with cyclosporin A was not effective, the patient was subsequently given a combination of antithymocyte globulin, cyclosporin A, and granulocyte colony-stimulating factor. Although the pancytopenia subsided, the percentage of double-negative erythrocytes in the patient's blood remained almost unchanged compared to findings obtained on admission.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Antilymphocyte Serum / therapeutic use*
  • Bone Marrow Diseases / complications*
  • Bone Marrow Diseases / pathology
  • Cyclosporine / therapeutic use*
  • Drug Therapy, Combination
  • Granulocyte Colony-Stimulating Factor / therapeutic use*
  • Hemoglobinuria, Paroxysmal / pathology
  • Hemoglobinuria, Paroxysmal / therapy*
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Male
  • Treatment Outcome

Substances

  • Antilymphocyte Serum
  • Immunosuppressive Agents
  • Granulocyte Colony-Stimulating Factor
  • Cyclosporine