Abstract
The polymerase (pol) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1, 237 codons. Almost all variation occurred outside of conserved functional domains where resistance mutations have been identified.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antiviral Agents / pharmacology*
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Codon
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Cytomegalovirus / drug effects*
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Cytomegalovirus / genetics
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DNA-Directed DNA Polymerase / chemistry*
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DNA-Directed DNA Polymerase / genetics
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Drug Resistance, Microbial
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Foscarnet / pharmacology
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Ganciclovir / pharmacology
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Genotype
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Humans
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Sequence Homology, Amino Acid
Substances
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Antiviral Agents
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Codon
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Foscarnet
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DNA-Directed DNA Polymerase
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Ganciclovir