Abstract
Ginseng sapogenins were produced from ginseng saponins, isolated from Korean ginseng roots. Ginseng saponins very mildly inhibited acyl-CoA:cholesterol acyltransferase (ACAT) in vitro, however, the sapogenins showed strong inhibitory activity on microsomal ACAT. Therefore, the sapogenins will be one of key ingredients of ginseng affected a lowering of the serum total cholesterol level.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticholesteremic Agents / chemistry
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Anticholesteremic Agents / isolation & purification
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Anticholesteremic Agents / pharmacology
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Microsomes, Liver / drug effects
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Microsomes, Liver / enzymology
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Panax / chemistry*
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Plants, Medicinal*
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Rats
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Sapogenins / chemistry
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Sapogenins / isolation & purification
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Sapogenins / pharmacology*
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Saponins / chemistry*
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Sterol O-Acyltransferase / antagonists & inhibitors*
Substances
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Anticholesteremic Agents
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Enzyme Inhibitors
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Sapogenins
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Saponins
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Sterol O-Acyltransferase