Abstract
Bioactivity-guided fractionation of the CHCl3 extract from hooks of Uncaria rhynchophylla led to the isolation of two triterpene esters, namely uncarinic acids A (1) and B (2). Their structures were established by spectroscopic and chemical methods. These compounds inhibited phospholipase Cgamma1 with IC50 values of 35.66 and 44.55 microM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Division / drug effects
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Humans
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Isoenzymes / antagonists & inhibitors*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Oleanolic Acid / analogs & derivatives*
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Oleanolic Acid / chemistry
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Oleanolic Acid / isolation & purification
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Oleanolic Acid / pharmacology
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Phospholipase C gamma
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Rubiaceae / chemistry*
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Tumor Cells, Cultured
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Type C Phospholipases / antagonists & inhibitors*
Substances
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Enzyme Inhibitors
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Isoenzymes
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uncarinic acid A
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Oleanolic Acid
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Type C Phospholipases
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Phospholipase C gamma