Early T cell receptor beta gene expression is regulated by the pre-T cell receptor-CD3 complex

I Aifantis; J Feinberg; H J Fehling; J P Di Santo; H von Boehmer

doi:10.1084/jem.190.1.141

Early T cell receptor beta gene expression is regulated by the pre-T cell receptor-CD3 complex

J Exp Med. 1999 Jul 5;190(1):141-4. doi: 10.1084/jem.190.1.141.

Authors

I Aifantis¹, J Feinberg, H J Fehling, J P Di Santo, H von Boehmer

Affiliation

¹ Institut National de la Santé et de la Recherche Médicale (INSERM) U373, Hôpital Necker-Enfants Malades, Paris, France.

Abstract

We have examined the question of whether there is an additional checkpoint in T cell development that regulates T cell receptor (TCR)-beta expression in CD25+44- thymocytes by mechanisms that are independent of the pre-TCR. Our analysis in various mutant mice indicates that all changes in cytoplasmic TCR-beta expression can be accounted for by pre-TCR-dependent signal mediation, putting into question the function of a putative pro-TCR.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
CD3 Complex / physiology*
CD4 Antigens / analysis
CD8 Antigens / analysis
Gene Expression Regulation*
Membrane Glycoproteins / physiology*
Mice
Mice, Inbred C57BL
Receptors, Antigen, T-Cell, alpha-beta / genetics*
Receptors, Interleukin-2 / immunology
T-Lymphocytes / immunology
T-Lymphocytes / metabolism

Substances

CD3 Complex
CD4 Antigens
CD8 Antigens
Membrane Glycoproteins
Receptors, Antigen, T-Cell, alpha-beta
Receptors, Interleukin-2
pre-T cell receptor alpha