Stereospecific synthesis and antiviral activities of beta-L-2',3'-dideoxy-5-chloropyrimidine nucleoside derivatives

C Pierra; G Gosselin; J P Sommadossi; A Faraj; E De Clercq; J Balzarini; J L Imbach

doi:10.1080/15257779908041526

Stereospecific synthesis and antiviral activities of beta-L-2',3'-dideoxy-5-chloropyrimidine nucleoside derivatives

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):643-4. doi: 10.1080/15257779908041526.

Authors

C Pierra¹, G Gosselin, J P Sommadossi, A Faraj, E De Clercq, J Balzarini, J L Imbach

Affiliation

¹ Laboratoire de Chimie Bioorganique, UMR CNRS 5625, Université de Montpellier II, France.

PMID: 10432657
DOI: 10.1080/15257779908041526

Abstract

Several 5-chlorouracil and 5-chlorocytosine beta-L-dideoxynucleosides were stereospecifically synthesized and their activities against human immunodeficiency virus (HIV) and hepatitis B virus (HBV) were examined in cell culture.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemical synthesis
Antiviral Agents / pharmacology*
Cell Line
Cells, Cultured
Dideoxynucleosides / chemical synthesis*
Dideoxynucleosides / pharmacology*
HIV / drug effects
Hepatitis B virus / drug effects
Microbial Sensitivity Tests
Pyrimidine Nucleosides / chemical synthesis*
Pyrimidine Nucleosides / pharmacology*

Substances

Antiviral Agents
Dideoxynucleosides
Pyrimidine Nucleosides