Comparison of anti-HBV activity of beta-D- and beta-L-DDA-5'monophosphate prodrugs and effectiveness in combination with lamivudine

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):1005-6. doi: 10.1080/15257779908041630.

Abstract

We have investigated the effects of several beta-D-ddA 5'-monophospate (beta-D-ddAMP), and their corresponding beta-L-enantiomers prodrugs against HBV replication. All ddAMP prodrugs inhibited HBV replication in a dose-dependent manner.

Publication types

  • Comparative Study

MeSH terms

  • Antiviral Agents / pharmacology*
  • Cell Line
  • Deoxyadenine Nucleotides / pharmacology*
  • Dideoxynucleotides
  • Hepatitis B virus / drug effects*
  • Hepatitis B virus / physiology
  • Lamivudine / pharmacology*
  • Microbial Sensitivity Tests
  • Stereoisomerism
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • Deoxyadenine Nucleotides
  • Dideoxynucleotides
  • 2',3'-dideoxyadenosine 5'-phosphate
  • Lamivudine