Interactions of HIV-1 with antigen-presenting cells

Immunol Cell Biol. 1999 Aug;77(4):289-303. doi: 10.1046/j.1440-1711.1999.00833.x.

Abstract

There is currently much interest in the numerical and functional loss of antigen-presenting cells (APC) in HIV-1 disease and the contribution that this may make to HIV-1 pathology. The HIV-1 virus can interfere with the normal function of APC in a number of ways involving inappropriate signalling. These include changes in cytokine balance, cell-surface molecule expression and intracellular signalling pathways. This review examines how HIV-1 is able to disregulate APC function and discusses possible outcomes for the function of the immune system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antigen-Presenting Cells / immunology*
  • Antigen-Presenting Cells / virology
  • Apoptosis
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / virology
  • Cytokines / biosynthesis
  • HIV Antigens
  • HIV Envelope Protein gp120 / immunology
  • HIV Infections / etiology
  • HIV Infections / immunology
  • HIV Infections / virology
  • HIV-1 / genetics
  • HIV-1 / immunology*
  • HIV-1 / pathogenicity*
  • HLA Antigens / genetics
  • Humans
  • Membrane Fusion
  • Polymorphism, Genetic
  • Receptors, HIV / genetics
  • Signal Transduction
  • T-Lymphocytes, Helper-Inducer / classification
  • T-Lymphocytes, Helper-Inducer / immunology
  • Virus Replication

Substances

  • Cytokines
  • HIV Antigens
  • HIV Envelope Protein gp120
  • HLA Antigens
  • Receptors, HIV