Targeting nitric oxide to cancer cells: cytotoxicity studies of glyco-S-nitrosothiols

Bioorg Med Chem Lett. 1999 Aug 2;9(15):2255-8. doi: 10.1016/s0960-894x(99)00363-7.

Abstract

Glyco-S-nitrosothiols, fructose-2-SNAP and glucose-2-SNAP, were synthesized and found to be much more cytotoxic than SNAP in killing DU-145 human prostate cancer cells in vitro.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Drug Screening Assays, Antitumor
  • Fructose / analogs & derivatives*
  • Fructose / chemical synthesis
  • Fructose / pharmacology
  • Glucose / analogs & derivatives*
  • Glucose / chemical synthesis
  • Glucose / pharmacology
  • Humans
  • Male
  • Nitric Oxide / metabolism*
  • Nitric Oxide Donors / pharmacology
  • Nitroso Compounds / chemical synthesis*
  • Nitroso Compounds / pharmacology
  • Penicillamine / analogs & derivatives
  • Penicillamine / pharmacology
  • Prostatic Neoplasms / pathology
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Nitric Oxide Donors
  • Nitroso Compounds
  • S-nitro-N-acetylpenicillamine
  • fructose-2-SNAP
  • glucose-2-SNAP
  • Fructose
  • Nitric Oxide
  • Penicillamine
  • Glucose