Abstract
Smoking and demographic variables are known to be risk factors for the development of thyroid-associated orbitopathy (TAO) among patients with Graves' hyperthyroidism, but a firm genetic basis for TAO has not been established. We show that the presence and severity of TAO are associated with an allele of the cytotoxic T lymphocyte antigen-4-gene.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Abatacept
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Alleles
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Antigens, CD
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Antigens, Differentiation / genetics*
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CTLA-4 Antigen
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Child
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Female
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Genetic Markers / genetics
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Genetic Predisposition to Disease / genetics*
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Graves Disease / genetics*
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Graves Disease / immunology
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Humans
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Immunoconjugates*
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Male
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Middle Aged
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Polymorphism, Genetic / genetics*
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Risk Factors
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T-Lymphocytes, Cytotoxic / immunology*
Substances
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Antigens, CD
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Antigens, Differentiation
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CTLA-4 Antigen
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CTLA4 protein, human
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Genetic Markers
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Immunoconjugates
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Abatacept