Abstract
High-dose thiotepa has been successfully included in a variety of conditioning regimens for stem cell transplantation in hematological and solid neoplasms. Toxicity of high-dose thiotepa mainly manifests as profound myeloablation and some degree of liver damage. We report a case of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with primary CNS lymphoma who underwent therapy with high-dose thiotepa.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Brain Neoplasms / drug therapy
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Brain Neoplasms / radiotherapy
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Brain Neoplasms / therapy
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Combined Modality Therapy
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Cranial Irradiation
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Female
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Hematopoietic Stem Cell Transplantation
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Humans
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Inappropriate ADH Syndrome / chemically induced*
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Lymphoma, Non-Hodgkin / drug therapy
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Lymphoma, Non-Hodgkin / radiotherapy
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Lymphoma, Non-Hodgkin / therapy
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Thiotepa / administration & dosage
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Thiotepa / adverse effects*
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Transplantation Conditioning / adverse effects*