N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity

J Med Chem. 1999 Sep 23;42(19):3779-84. doi: 10.1021/jm990254z.
No abstract available

MeSH terms

  • Alkyl and Aryl Transferases / antagonists & inhibitors*
  • Animals
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology
  • Farnesyltranstransferase
  • Humans
  • Imidazoles / chemical synthesis*
  • Imidazoles / pharmacology
  • Mice
  • Mice, Nude
  • Models, Molecular
  • Piperazines / chemical synthesis*
  • Piperazines / pharmacology
  • Rats
  • Tumor Cells, Cultured

Substances

  • Enzyme Inhibitors
  • Imidazoles
  • Piperazines
  • Alkyl and Aryl Transferases
  • Farnesyltranstransferase