A novel sesterterpenoid, nitiol, as a potent enhancer of IL-2 gene expression in a human T cell line, from the Peruvian folk medicine "Hercumpuri" (Gentianella nitida)

N Kawahara; M Nozawa; A Kurata; T Hakamatsuka; S Sekita; M Satake

doi:10.1248/cpb.47.1344

A novel sesterterpenoid, nitiol, as a potent enhancer of IL-2 gene expression in a human T cell line, from the Peruvian folk medicine "Hercumpuri" (Gentianella nitida)

Chem Pharm Bull (Tokyo). 1999 Sep;47(9):1344-5. doi: 10.1248/cpb.47.1344.

Authors

N Kawahara¹, M Nozawa, A Kurata, T Hakamatsuka, S Sekita, M Satake

Affiliation

¹ National Institute of Health Sciences (NIHS), Tokyo, Japan.

PMID: 10517015
DOI: 10.1248/cpb.47.1344

Abstract

A novel sesterterpenoid designated as nitiol (1), possessing enhancement activity of IL-2 gene expression in a human T cell line, was isolated from the Peruvian folk medicine "Hercampuri" (Gentianella nitida). The structure was elucidated by extensive spectroscopic investigation.

MeSH terms

Cells, Cultured
Gene Expression Regulation / drug effects*
Humans
Interleukin-2 / biosynthesis*
Interleukin-2 / genetics
Jurkat Cells / drug effects
Jurkat Cells / metabolism
Magnetic Resonance Spectroscopy
Peru
Plants, Medicinal / chemistry*
RNA, Messenger / biosynthesis
T-Lymphocytes / drug effects
T-Lymphocytes / metabolism*
Terpenes / isolation & purification*
Terpenes / pharmacology

Substances

Interleukin-2
RNA, Messenger
Terpenes
nitiol