"Gating" of human short-latency somatosensory evoked cortical responses during execution of movement. A high resolution electroencephalography study

Brain Res. 1999 Oct 2;843(1-2):161-70. doi: 10.1016/s0006-8993(99)01716-3.

Abstract

The present study aimed at investigating gating of median nerve somatosensory evoked cortical responses (SECRs), estimated during executed continuous complex ipsilateral and contralateral sequential finger movements. SECRs were modeled with an advanced high resolution electroencephalography technology that dramatically improved spatial details of the scalp recorded somatosensory evoked potentials. Integration with magnetic resonance brain images allowed us to localize different SECRs within cortical areas. The working hypothesis was that the gating effects were time varying and could differently influence SECRs. Maximum statistically significant (p<0. 01) time-varying gating (magnitude reduction) of the short-latency SECRs modeled in the contralateral primary motor and somatosensory and supplementary motor areas was computed during the executed ipsilateral movement. The gating effects were stronger on the modeled SECRs peaking 30-45 ms (N30-P30, N32, P45-N45) than 20-26 ms (P20-N20, P22, N26) post-stimulus. Furthermore, the modeled SECRs peaking 30 ms post-stimulus (N30-P30) were significantly increased in magnitude during the executed contralateral movement. These results may delineate a distributed cortical sensorimotor system responsible for the gating effects on SECRs. This system would be able to modulate activity of SECR generators, based on the integration of afferent somatosensory inputs from the stimulated nerve with outputs related to the movement execution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain Mapping*
  • Electroencephalography / methods*
  • Evoked Potentials, Somatosensory / physiology*
  • Fingers / innervation
  • Fingers / physiology
  • Functional Laterality
  • Humans
  • Male
  • Motor Activity / physiology*
  • Motor Cortex / physiology*
  • Psychomotor Performance
  • Reaction Time / physiology
  • Somatosensory Cortex / physiology*