Pathology of angiosarcoma of the liver among vinyl chloride-polyvinyl chloride workers

Ann N Y Acad Sci. 1975 Jan 31:246:268-77. doi: 10.1111/j.1749-6632.1975.tb51102.x.

Abstract

We described the histologic features of 13 hepatic angiosarcomas which developed in workers engaged in the polymerization of vinyl chloride to polyvinyl chloride. Although the histologic features varied considerably in different portions of the angiosarcoma in the same liver and in the angiosarcomas of the liver from different patients, many features were similar such as sinusoidal, papillary, and cavernous growth patterns coincident with the precursor lesions of proliferation and atypia of sinusoidal lining cells.

MeSH terms

  • Hemangiosarcoma / chemically induced
  • Hemangiosarcoma / pathology*
  • Humans
  • Liver / pathology*
  • Liver Neoplasms / chemically induced
  • Liver Neoplasms / pathology*
  • Male
  • Middle Aged
  • Occupational Diseases / chemically induced*
  • Polyvinyl Chloride / poisoning*
  • Polyvinyls / poisoning*
  • Vinyl Chloride / poisoning*
  • Vinyl Compounds / poisoning*

Substances

  • Polyvinyls
  • Vinyl Compounds
  • Polyvinyl Chloride
  • Vinyl Chloride