Intestinal tachyarrhythmias during small bowel ischemia

Am J Physiol. 1999 Nov;277(5):G993-9. doi: 10.1152/ajpgi.1999.277.5.G993.

Abstract

The electrical control activity (ECA) of the bowel is the omnipresent slow electrical wave of the intestinal tract. Characterization of small bowel electrical activity during ischemia may be used as a measure of intestinal viability. With the use of an animal model of mesenteric ischemia, serosal electrodes and a digital recording apparatus utilizing autoregressive spectral analysis were used to monitor the ECA of 20 New Zealand White rabbits during various lengths of ischemia. ECA frequency fell from 18.2 +/- 0.5 cycles per minute (cpm) at baseline to 12.2 +/- 0.9 cpm (P < 0.05) after 30 min of ischemia and was undetectable by 90 min of ischemia in all animals. Tachyarrhythmias of the ECA were recorded in 55% of the animals as early as 25 min after ischemia was induced and lasted from 1 to 48 min. Frequencies ranged from 25 to 50 cpm. These tachyarrhythmias were seen only during ischemia, suggesting that they are pathognomonic for intestinal ischemia. The use of the detection of ECA changes during intestinal ischemia may allow earlier diagnosis of mesenteric ischemia.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Electrophysiology
  • Gastrointestinal Motility / physiology
  • Intestine, Small / blood supply*
  • Intestine, Small / physiopathology*
  • Ischemia / diagnosis*
  • Ischemia / physiopathology*
  • Male
  • Mesenteric Arteries / physiopathology
  • Periodicity
  • Predictive Value of Tests
  • Prognosis
  • Rabbits