Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists

J Med Chem. 1999 Nov 4;42(22):4473-8. doi: 10.1021/jm991114s.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding, Competitive
  • Brain / metabolism
  • CHO Cells
  • Cricetinae
  • Cyclic AMP / biosynthesis
  • Humans
  • In Vitro Techniques
  • Purinergic P1 Receptor Antagonists*
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / chemistry
  • Pyrazoles / metabolism
  • Pyrazoles / pharmacology
  • Pyrimidines / chemical synthesis*
  • Pyrimidines / chemistry
  • Pyrimidines / metabolism
  • Pyrimidines / pharmacology
  • Rats
  • Receptor, Adenosine A3
  • Receptors, Purinergic P1 / metabolism
  • Structure-Activity Relationship

Substances

  • Purinergic P1 Receptor Antagonists
  • Pyrazoles
  • Pyrimidines
  • Receptor, Adenosine A3
  • Receptors, Purinergic P1
  • Cyclic AMP