Abstract
Alterations in the hypocretin receptor 2 and preprohypocretin genes produce narcolepsy in animal models. Hypocretin was undetectable in seven out of nine people with narcolepsy, indicating abnormal hypocretin transmission.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Animals
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Carrier Proteins*
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Dogs
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Female
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Humans
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Intracellular Signaling Peptides and Proteins*
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Male
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Mice
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Mice, Knockout
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Middle Aged
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Narcolepsy / cerebrospinal fluid
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Narcolepsy / genetics
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Narcolepsy / metabolism*
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Neuropeptides*
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Neurotransmitter Agents / cerebrospinal fluid
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Neurotransmitter Agents / deficiency*
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Neurotransmitter Agents / genetics
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Orexins
Substances
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Carrier Proteins
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Intracellular Signaling Peptides and Proteins
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Neuropeptides
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Neurotransmitter Agents
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Orexins