Incorrect diagnosis of diabetes mellitus in a patient with persistence of fetal haemoglobin

Int J Clin Pract. 1998 Oct;52(7):511-2.

Abstract

A 65-year-old woman, referred to the endocrine clinic for investigation of tiredness and arthritis, was diagnosed as having diabetes on the basis of a positive family history and a raised glycated haemoglobin (HbA1) measurement. Subsequently, she was shown not to have diabetes but to have a persistently raised haemoglobin F (HbF) level. Initial assessment of HbF level by electroendosmosis demonstrated a normal HbF level but high values were confirmed using HPLC. Thalassaemia was excluded following DNA analysis. This case illustrates the importance of a glucose tolerance test following WHO criteria for the diagnosis of diabetes and emphasises that HbA1 is not a diagnostic test for diabetes.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Chromatography, High Pressure Liquid
  • Diabetes Mellitus / diagnosis*
  • Diagnostic Errors*
  • Female
  • Fetal Hemoglobin / metabolism*
  • Hemoglobin A / metabolism*
  • Humans

Substances

  • Hemoglobin A
  • Fetal Hemoglobin