[Glyciram as an enhancer of the effectiveness of chemotherapy and surgery in the treatment of experimental neoplasms]

T G Razina; E P Zueva; E N Amosova; V V Zhdanov

[Glyciram as an enhancer of the effectiveness of chemotherapy and surgery in the treatment of experimental neoplasms]

Vopr Onkol. 1999;45(5):554-6.

[Article in Russian]

Authors

T G Razina¹, E P Zueva, E N Amosova, V V Zhdanov

Affiliation

¹ Research Institute of Pharmacology, Siberian Branch of Russian Academy of Medical Sciences, Tomsk.

PMID: 10629717

Abstract

Glycyrramum was shown to potentiate the antitumor and antimetastatic effects of cyclophosphamide treatment in mice and rats with transplantable tumors. It also decreased its myelotoxicity. After primary Lewis lung carcinoma was removed glycyrramum treatment significantly inhibited metastacizing processes in mice.

Publication types

English Abstract

MeSH terms

Animals
Antineoplastic Agents / pharmacology*
Antineoplastic Agents, Alkylating / pharmacology
Carcinoma, Lewis Lung / drug therapy*
Carcinoma, Lewis Lung / prevention & control
Carcinoma, Lewis Lung / secondary
Carcinoma, Lewis Lung / surgery
Cyclophosphamide / pharmacology
Drug Synergism
Female
Glycyrrhetinic Acid / pharmacology*
Mice
Mice, Inbred C57BL
Rats

Substances

Antineoplastic Agents
Antineoplastic Agents, Alkylating
Cyclophosphamide
Glycyrrhetinic Acid