Enantioselective

Angew Chem Int Ed Engl. 1999 Dec 16;38(24):3741-3743. doi: 10.1002/(sici)1521-3773(19991216)38:24<3741::aid-anie3741>3.0.co;2-5.

Abstract

Even with only a catalytic amount of chiral bis(dihydrooxazole) 1 as external ligand, the rearrangement of benzyl ethers to alcohols [Eq. (1)] proceeds with high enantioselectivity (over 60 % ee). This reaction represents the first example of an enantioselective [1,2] Wittig rearrangement.