Abstract
The polymerisation of haemoglobin-derived ferri-protoporphyrin IX (Fe(III)PPIX) to haemozoin (malaria pigment) is a crucial process for intraerythrocytic plasmodia to prevent haem toxicity. It is also the target of in-use antimalarial drugs and newer compounds. This reaction and the inhibition thereof can be reproduced and studied in vitro.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / pharmacology*
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Cells, Cultured
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Electrochemistry
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Erythrocytes / parasitology*
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Heme / metabolism*
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Hemeproteins / metabolism*
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Hemin / metabolism
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Humans
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Oxidation-Reduction
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Plasmodium / metabolism*
Substances
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Antimalarials
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Hemeproteins
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hemozoin
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Heme
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Hemin