Design and synthesis of functionalized glycomers as non-peptidic ligands for SH2 binding and as inhibitors of A-431 human epidermoid and HT-29 colon carcinoma cell lines

Bioorg Med Chem Lett. 2000 Mar 6;10(5):439-42. doi: 10.1016/s0960-894x(00)00022-6.

Abstract

A set of O-substituted aryl beta-D-glucopyranosides were prepared and found to have inhibitory activity on the growth of two carcinoma cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Carcinoma, Squamous Cell / drug therapy
  • Glucosides / chemical synthesis*
  • Glucosides / pharmacology
  • HT29 Cells
  • Humans
  • Ligands
  • Molecular Conformation
  • Tumor Cells, Cultured
  • src Homology Domains / drug effects*

Substances

  • Antineoplastic Agents
  • Glucosides
  • Ligands