Assessment of flhDC mRNA levels in Serratia liquefaciens swarm cells

J Bacteriol. 2000 May;182(10):2680-6. doi: 10.1128/JB.182.10.2680-2686.2000.

Abstract

We reported previously that artificial overexpression of the flhDC operon in liquid-grown Serratia liquefaciens resulted in the formation of filamentous, multinucleated, and hyperflagellated cells that were indistinguishable from surface-induced swarm cells (L. Eberl, G. Christiansen, S. Molin, and M. Givskov, J. Bacteriol. 178:554-559, 1996). In the present report we show by means of reporter gene measurements, Northern analysis, and in situ reverse transcription-PCR that the amount of flhDC mRNA in surface-grown swarm cells does not exceed the maximum level found in nondifferentiated, vegetative cells. This suggests that surface-induced S. liquefaciens swarm cell differentiation, although dependent on flhDC gene expression, does not occur through elevated flhDC mRNA levels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / analysis
  • Bacterial Proteins / genetics
  • DNA-Binding Proteins / analysis*
  • DNA-Binding Proteins / genetics
  • Escherichia coli Proteins
  • Gene Expression
  • Gene Expression Regulation, Bacterial / drug effects
  • Isopropyl Thiogalactoside / pharmacology
  • Operon
  • RNA, Bacterial / analysis
  • RNA, Messenger / analysis
  • Recombinant Fusion Proteins / genetics
  • Serratia / drug effects
  • Serratia / genetics*
  • Serratia / growth & development*
  • Trans-Activators / analysis*
  • Trans-Activators / genetics

Substances

  • Bacterial Proteins
  • DNA-Binding Proteins
  • Escherichia coli Proteins
  • RNA, Bacterial
  • RNA, Messenger
  • Recombinant Fusion Proteins
  • Trans-Activators
  • flhC protein, E coli
  • flhD protein, E coli
  • Isopropyl Thiogalactoside