Improvement of cystic fibrosis using antitumoral drugs: a hypothesis

Med Hypotheses. 2000 Apr;54(4):580-1. doi: 10.1054/mehy.1999.0899.

Abstract

The improvement of cystic fibrosis using antitumoral drugs has been reported. The hypothesis of a somatic reduction to heterozygosity of the CFTR gene mutations by homologous recombination in lung epithelium is proposed.

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics
  • ATP-Binding Cassette Transporters / genetics
  • Adult
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Cystic Fibrosis / drug therapy*
  • Cystic Fibrosis / genetics
  • Cystic Fibrosis Transmembrane Conductance Regulator / genetics
  • Gene Expression Regulation / drug effects
  • Heterozygote
  • Humans
  • Multidrug Resistance-Associated Proteins

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • ATP-Binding Cassette Transporters
  • Antineoplastic Agents
  • CFTR protein, human
  • Multidrug Resistance-Associated Proteins
  • Cystic Fibrosis Transmembrane Conductance Regulator