Prevalence of CCR5 and CCR2 HIV-coreceptor gene polymorphisms in Belgium

Hum Hered. 2000 Sep-Oct;50(5):304-7. doi: 10.1159/000022932.

Abstract

Polymorphisms of the chemokine receptor genes CCR5 and CCR2 are associated with resistance to HIV-1 infection or delayed progression to AIDS. Few data are available on their combined prevalence in healthy subjects; we therefore examined the occurrence of CCR5-Delta32 and CCR2-64I polymorphisms in a sample of 310 healthy Belgians. Allele frequencies were 0.119 and 0.074 for CCR5-Delta32 and CCR2-64I, respectively. Genotype distributions for both polymorphisms were found to be in accordance with Hardy-Weinberg equilibrium, but a significant (p = 0.002) linkage disequilibrium between CCR5-Delta32 and CCR2-64I was observed. The high prevalence of CCR5-Delta32 and CCR2-64I in Belgians may need to be taken into account in the design of studies of antiretroviral treatments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Belgium
  • Gene Frequency
  • Genotype
  • HIV-1*
  • Humans
  • Polymorphism, Genetic*
  • Prevalence
  • Receptors, CCR2
  • Receptors, CCR5 / genetics*
  • Receptors, Chemokine*
  • Receptors, Cytokine / genetics*
  • White People / genetics

Substances

  • CCR2 protein, human
  • Receptors, CCR2
  • Receptors, CCR5
  • Receptors, Chemokine
  • Receptors, Cytokine