Abstract
Respiratory syncytial virus (RSV) infection is a major cause of morbidity in childhood worldwide. The first human RSV-specific cytotoxic T-lymphocyte epitope to be defined is described. This HLA B7-restricted epitope in nucleoprotein (NP) was detectable in four healthy, B7-positive adult subjects using B7-RSV-NP tetrameric complexes to stain CD8(+) T cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Enzyme-Linked Immunosorbent Assay / methods
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Epitopes, T-Lymphocyte*
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Flow Cytometry
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HLA-B7 Antigen / metabolism
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Humans
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Respiratory Syncytial Virus Infections / immunology
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Respiratory Syncytial Virus Infections / virology
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Respiratory Syncytial Viruses / immunology*
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T-Lymphocytes, Cytotoxic / immunology*
Substances
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Epitopes, T-Lymphocyte
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HLA-B7 Antigen