Small peptides Do not inhibit human non-pancreatic secretory phospholipase-A(2) (Type IIA)

Biochem Biophys Res Commun. 2000 Aug 11;274(3):831-4. doi: 10.1006/bbrc.2000.3221.

Abstract

Seven small peptides, that are among the most potent reported inhibitors of secreted mammalian phospholipases A(2), were found not to inhibit processing of a small phospholipid substrate by human non-pancreatic secretory phospholipase A(2) (type IIa), under conditions where certain non-peptides are potent inhibitors at nanomolar concentrations.

MeSH terms

  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Peptides / chemistry
  • Peptides / pharmacology*
  • Phospholipases A / antagonists & inhibitors*
  • Substrate Specificity

Substances

  • Enzyme Inhibitors
  • Peptides
  • Phospholipases A