Does endogenous 5-HT mediate spontaneous rhythmic activity in chemoreceptor clusters of rat carotid body?

Brain Res. 2000 Jul 28;872(1-2):199-203. doi: 10.1016/s0006-8993(00)02499-9.

Abstract

Spontaneous voltage fluctuations often occurred during perforated-patch recordings from clustered rat carotid body (CB) chemoreceptors in vitro. This activity sometimes appeared as rhythmic-like spikes, when cluster size exceeded approximately 20 cells. Spike discharge could be augmented or induced by hypoxia or 5-HT (2-10 microM) application, and inhibited by the 5-HT receptor blocker, ketanserin (50-100 microM). Thus, endogenous 5-HT may contribute to spontaneous firing within CB receptor clusters via autocrine/paracrine mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Action Potentials / physiology
  • Animals
  • Autocrine Communication / physiology
  • Carotid Body / cytology
  • Carotid Body / drug effects
  • Carotid Body / metabolism*
  • Cell Hypoxia / physiology
  • Cells, Cultured
  • Chemoreceptor Cells / cytology
  • Chemoreceptor Cells / drug effects
  • Chemoreceptor Cells / metabolism*
  • Ketanserin / pharmacology
  • Paracrine Communication / physiology
  • Patch-Clamp Techniques
  • Periodicity*
  • Rats
  • Serotonin / metabolism*
  • Serotonin / pharmacology
  • Serotonin Antagonists / pharmacology

Substances

  • Serotonin Antagonists
  • Serotonin
  • Ketanserin