The report deals with such present-day invasive procedures of breast examination as X-ray-controlled puncture, puncture using X-ray contrast, Cytoguide video-accessory unit controlled puncture biopsy, "pistol-needle" application, ultrasound aiming puncture, pneumocystography, ductography and preoperative interstitial marking of nonpalpable masses. If latest invasive procedures are used during complex examination of the breast, diagnostic accuracy can be raised to 95-97%.