Abstract
The mef(A) gene from a clinical isolate of Streptococcus pneumoniae exhibiting the M-type resistance to macrolides was found to be part of the 7,244-bp chromosomal element Tn1207.1, which contained 8 open reading frames. orf2 encodes a resolvase/invertase, and orf5 is a homolog of the macrolide-streptogramin B resistance gene msr(SA).
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Bacterial Agents / metabolism*
-
Anti-Bacterial Agents / pharmacology
-
Bacterial Proteins*
-
Biological Transport
-
Chromosomes, Bacterial
-
DNA Transposable Elements / genetics
-
DNA, Bacterial / analysis
-
Drug Resistance, Microbial / genetics
-
Drug Resistance, Microbial / physiology
-
Humans
-
Macrolides
-
Membrane Proteins / genetics*
-
Membrane Proteins / metabolism
-
Molecular Sequence Data
-
Open Reading Frames
-
Sequence Analysis, DNA
-
Streptococcus pneumoniae / drug effects
-
Streptococcus pneumoniae / genetics*
-
Streptococcus pneumoniae / metabolism
-
Virginiamycin / pharmacology
Substances
-
Anti-Bacterial Agents
-
Bacterial Proteins
-
DNA Transposable Elements
-
DNA, Bacterial
-
Macrolides
-
MefA protein, Streptococcus
-
Membrane Proteins
-
Virginiamycin