Near full-length genome analysis of HIV type 1 CRF02.AG subtype C and CRF02.AG subtype G recombinants

W Janssens; M O Salminen; T Laukkanen; L Heyndrickx; van der Auwera; R Colebunders; F E McCutchan; G van der Groen

doi:10.1089/088922200415045

Near full-length genome analysis of HIV type 1 CRF02.AG subtype C and CRF02.AG subtype G recombinants

AIDS Res Hum Retroviruses. 2000 Aug 10;16(12):1183-9. doi: 10.1089/088922200415045.

Authors

W Janssens¹, M O Salminen, T Laukkanen, L Heyndrickx, van der Auwera, R Colebunders, F E McCutchan, G van der Groen

Affiliation

¹ Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium. wjanssens@itg.be

PMID: 10954895
DOI: 10.1089/088922200415045

Abstract

HIV-1 CRF02.AG strains are prevalent in west and west-central Africa, suggesting a longstanding presence of these subtype A/G recombinants in the global epidemic. Cocirculation of CRF02.AG strains with other group M subtypes may give rise to HIV-1 recombinants constituting a mosaic genome comprising fragments of three different subtypes. We report on the genetic analysis of the near-full-length genomes of such recombinants (VI1035 and VI1197) as well as CRF02.AG strains in Belgian individuals. VI1035 and VI1197 may be the result of successful "second-generation" recombinations of HIV-1 strains CRF02.AG with, respectively, subtype C (VI1035) and G (VI1197) strains in a dually infected individual.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Africa, Central
Africa, Western
Belgium
Genome, Viral*
HIV Infections / virology
HIV-1 / classification*
HIV-1 / genetics*
HIV-1 / isolation & purification
Humans
Phylogeny*
Recombination, Genetic*
Sequence Alignment