(S)-4-Methyl-2-(methylamino)pentanoic acid [4, 4-bis(4-fluorophenyl)butyl]amide hydrochloride, a novel calcium channel antagonist, is efficacious in several animal models of pain

J Med Chem. 2000 Sep 21;43(19):3474-7. doi: 10.1021/jm000134n.

Authors

Y Song¹, S S Bowersox, D T Connor, D J Dooley, S M Lotarski, T Malone, G Miljanich, E Millerman, M F Rafferty, D Rock, B D Roth, J Schmidt, S Stoehr, B G Szoke, C Taylor, M Vartanian, Y X Wang

Affiliation

¹ Pfizer Global Research and Development, Ann Arbor Laboratories, Pfizer Inc., 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA.

PMID: 11000000
DOI: 10.1021/jm000134n

No abstract available

MeSH terms

Administration, Oral
Analgesics, Non-Narcotic / chemistry
Analgesics, Non-Narcotic / pharmacology*
Animals
Calcium Channel Blockers / chemistry
Calcium Channel Blockers / pharmacology*
Calcium Channels, L-Type / drug effects
Calcium Channels, N-Type / drug effects
Cell Line
Injections, Intravenous
Male
Mice
Mice, Inbred DBA
Pain Measurement
Pentanoic Acids / chemistry
Pentanoic Acids / pharmacology*
Rats

Substances

4-methyl-2-(methylamino)pentanoic acid (4, 4-bis(4-fluorophenyl)butyl)amide
Analgesics, Non-Narcotic
Calcium Channel Blockers
Calcium Channels, L-Type
Calcium Channels, N-Type
Pentanoic Acids