Carbohydrate-modulated DNA photocleavage: design, synthesis, and evaluation of novel glycosyl anthraquinones

K Toshima; Y Maeda; H Ouchi; A Asai; S Matsumura

doi:10.1016/s0960-894x(00)00410-8

Carbohydrate-modulated DNA photocleavage: design, synthesis, and evaluation of novel glycosyl anthraquinones

Bioorg Med Chem Lett. 2000 Oct 2;10(19):2163-5. doi: 10.1016/s0960-894x(00)00410-8.

Authors

K Toshima¹, Y Maeda, H Ouchi, A Asai, S Matsumura

Affiliation

¹ Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan. toshima@applc.keio.ac.jp

PMID: 11012020
DOI: 10.1016/s0960-894x(00)00410-8

Abstract

Novel and artificial anthraquinone-carbohydrate hybrids were designed and synthesized, and found to effectively cleave DNA under irradiation with a long wavelength UV light and also exhibit cytotoxicity against HeLa S3 cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anthraquinones / chemical synthesis*
Anthraquinones / chemistry
Anthraquinones / metabolism*
Anthraquinones / pharmacology
Carbohydrate Metabolism
Carbohydrates / chemical synthesis*
Carbohydrates / chemistry
Carbohydrates / pharmacology
Cell Survival / drug effects
DNA / metabolism*
HeLa Cells
Humans
Intercalating Agents / metabolism
Molecular Structure
Photolysis / drug effects*
Ultraviolet Rays

Substances

Anthraquinones
Carbohydrates
Intercalating Agents
DNA