Abstract
Long-term administration of the common sea buckthorn bark and sprout extract improves the hormonal-metabolic organism status in rats disturbed by a stress factor (immobilization). The drug administration led to normalization of the altered functional activity indices of the neuro-endocrine system (disturbed adrenocorticotropin, 11-deoxycortisol, insulin, urea, and glucose levels) by affecting the production of glucocorticoids and increasing the hypothalamus sensitivity with respect to regulatory signals.
MeSH terms
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Adrenocorticotropic Hormone / metabolism
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Adrenocorticotropic Hormone / pharmacology
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Animals
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Blood Glucose / metabolism
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Cortodoxone / blood
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Dexamethasone / pharmacology
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Homeostasis
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Hormones / metabolism*
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Hypothalamo-Hypophyseal System / drug effects
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Insulin / blood
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Pituitary-Adrenal System / drug effects
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Plant Extracts / therapeutic use*
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Plant Stems / chemistry
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Rats
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Rats, Wistar
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Stress, Physiological / drug therapy*
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Stress, Physiological / metabolism
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Urea / blood
Substances
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Blood Glucose
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Hormones
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Insulin
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Plant Extracts
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Dexamethasone
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Urea
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Adrenocorticotropic Hormone
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Cortodoxone