p53 codon 72 polymorphism in vulval cancer and vulval intraepithelial neoplasia

A N Rosenthal; A Ryan; D Hopster; I J Jacobs

doi:10.1054/bjoc.2000.1419

p53 codon 72 polymorphism in vulval cancer and vulval intraepithelial neoplasia

Br J Cancer. 2000 Nov;83(10):1287-90. doi: 10.1054/bjoc.2000.1419.

Authors

A N Rosenthal¹, A Ryan, D Hopster, I J Jacobs

Affiliation

¹ Department of Gynaecological Oncology, Academic Department of Histopathology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, West Smithfield, London, EC1A 7BE, UK.

Abstract

p53 codon 72 polymorphism was analysed in UK women with human papillomavirus (HPV)-associated vulval intraepithelial neoplasia and vulval squamous cell carcinoma. Arginine homozygotes were significantly less common in either group compared with controls. We conclude that the arginine polymorphism may confer protection against the development of HPV-associated vulval neoplasia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Arginine / chemistry
Carcinoma in Situ / etiology
Carcinoma in Situ / genetics*
Carcinoma in Situ / virology
Carcinoma, Squamous Cell / etiology
Carcinoma, Squamous Cell / genetics*
Carcinoma, Squamous Cell / virology
Codon / genetics
Female
Genes, p53 / genetics*
Humans
Papillomaviridae*
Papillomavirus Infections / complications*
Polymorphism, Genetic*
Tumor Virus Infections / complications*
Vulvar Neoplasms / etiology
Vulvar Neoplasms / genetics*
Vulvar Neoplasms / virology

Substances

Codon
Arginine