Application of multishot acquisition in Fourier transform mass spectrometry

Anal Chem. 2000 Oct 15;72(20):5125-30. doi: 10.1021/ac0005565.

Abstract

A new method of ion injection and trapping is discussed wherein ions are accumulated over several laser shots in the FT-ICR cell prior to detection. This allows accumulation of ion signal without accumulating noise so that the signal/noise ratio is much improved provided that the "space-charge" limit of the total number of ions in the cell is not exceeded. "In-cell" ion accumulation allows selected ion accumulation by simply sweeping unwanted ions out of the cell prior to subsequent ion trapping events and also allows shifted ion accumulations to correct for time-of-flight distortions in the ion abundance distributions.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Mass Spectrometry / methods*
  • Spectroscopy, Fourier Transform Infrared