Abstract
The human heat-inducible Hsp70B and Hsp70B' genes were co-localized to 1q23.1 by in situ hybridization. However, though transcripts from Hsp70B could be detected in heat-shocked cells, DNA sequence analyses of both the gene and cDNA copies of the mRNA indicate the gene is non-functional. Moreover, mouse homologues of Hsp70B/B' were not detected by Southern blot analysis, suggesting Hsp70B/B' arose from either Hsp70-1or Hsp70-2 after the divergence of mice and humans.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Blotting, Southern
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Chromosomes, Human, Pair 1 / genetics*
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Evolution, Molecular
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HSP70 Heat-Shock Proteins / genetics*
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HSP70 Heat-Shock Proteins / physiology*
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Heat-Shock Response / genetics*
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Humans
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In Situ Hybridization, Fluorescence
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Mice
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Molecular Sequence Data
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Physical Chromosome Mapping
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Promoter Regions, Genetic / genetics
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RNA, Messenger / analysis
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RNA, Messenger / genetics
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Sequence Homology, Nucleic Acid
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Transcription, Genetic / genetics*
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Tumor Cells, Cultured
Substances
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HSP70 Heat-Shock Proteins
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HSPA7 protein, human
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RNA, Messenger