Psychophysiological correlates of social skills deficits in persons with schizophrenia

Psychiatry Res. 2000 Dec 22;100(3):155-67. doi: 10.1016/s0925-4927(00)00077-9.

Abstract

Social skill deficits in schizophrenia profoundly affect patients' life-long outcome, although the profile of the underlying cognitive dysfunction still remains a matter of debate. In the present study, we investigated the relationship between social skills and event-related potentials (ERPs) in an auditory selective attention task, in addition to the neurocognitive indices obtained from the degraded-stimulus continuous performance test (CPT) and clinical indices, such as Brief Psychiatric Rating Scale (BRPS) and global assessment of function (GAF) scores. Social skills were assessed using a Japanese version of the structured role play test. Fourteen persons with schizophrenia participated in the study. Non-verbal skills showed a positive correlation with GAF, the performance level, N1 and N2b amplitude in the ERP task, and hit rate in the CPT, and a negative correlation with reaction time in the CPT. Verbal communication skills showed a positive correlation with GAF, the performance level and N2b amplitude in the ERP task, and hit rate in the CPT, and a negative correlation with reaction time in the CPT. Processing skills showed a positive correlation with the performance level and N1 amplitude in the ERP task and a negative correlation with reaction time in the CPT. These findings suggested that the social skill deficits of persons with schizophrenia were related to the vigilance level and controlled stimulus detection processing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Attention / physiology
  • Brain Mapping
  • Cerebral Cortex / physiopathology
  • Dominance, Cerebral / physiology
  • Electroencephalography*
  • Evoked Potentials, Auditory / physiology
  • Female
  • Humans
  • Interpersonal Relations
  • Male
  • Neuropsychological Tests
  • Pitch Perception / physiology
  • Psychiatric Status Rating Scales
  • Psychomotor Performance / physiology
  • Reaction Time / physiology
  • Role Playing
  • Schizophrenia / diagnosis
  • Schizophrenia / physiopathology*
  • Schizophrenic Psychology*
  • Self Efficacy
  • Social Behavior Disorders / diagnosis
  • Social Behavior Disorders / physiopathology*
  • Social Behavior Disorders / psychology