Conservation of small-airway function by tacrolimus/cyclosporine conversion in the management of bronchiolitis obliterans following lung transplantation

J Heart Lung Transplant. 2000 Dec;19(12):1219-23. doi: 10.1016/s1053-2498(00)00206-0.

Abstract

We studied serial lung function in 11 patients with bronchiolitis obliterans syndrome who were treated with tacrolimus conversion following lung or heart-lung transplantation. Our results show that tacrolimus conversion slows the decline of lung function in bronchiolitis obliterans syndrome. The attenuation continues for at least 1 year following conversion.

MeSH terms

  • Biopsy
  • Bronchi / physiopathology*
  • Bronchiolitis Obliterans / drug therapy*
  • Cyclosporine / therapeutic use*
  • Disease Progression
  • Follow-Up Studies
  • Forced Expiratory Volume / drug effects
  • Heart-Lung Transplantation* / physiology
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Lung Transplantation* / physiology
  • Maximal Midexpiratory Flow Rate / drug effects
  • Retrospective Studies
  • Spirometry
  • Statistics, Nonparametric
  • Syndrome
  • Tacrolimus / therapeutic use*

Substances

  • Immunosuppressive Agents
  • Cyclosporine
  • Tacrolimus