Is tissue plasminogen activator a threat to neurons?

S F Traynelis; S A Lipton

doi:10.1038/83289

Is tissue plasminogen activator a threat to neurons?

Nat Med. 2001 Jan;7(1):17-8. doi: 10.1038/83289.

Authors

S F Traynelis¹, S A Lipton

Affiliation

¹ Department of Pharmacology, Emory University, Atlanta, Georgia, USA. strayne@emory.edu

PMID: 11135603
DOI: 10.1038/83289

Abstract

The clot-busting drug tissue plasminogen activator (tPA) is currently the only FDA-approved therapy for acute stroke. However, increasing evidence suggests that tPA can also contribute to excitotoxic neuronal damage in animal models of stroke.

Publication types

Comment

MeSH terms

Animals
Disease Models, Animal
Neurons / drug effects*
Neurons / pathology
Receptors, N-Methyl-D-Aspartate / metabolism
Stroke / drug therapy*
Stroke / pathology
Tissue Plasminogen Activator / therapeutic use*

Substances

Receptors, N-Methyl-D-Aspartate
Tissue Plasminogen Activator