Radiosynthesis of [123I]betaCIT, a selective ligand for the study of the dopaminergic and serotoninergic systems in human brain

Appl Radiat Isot. 2001 Jan;54(1):93-5. doi: 10.1016/s0969-8043(00)00179-2.

Abstract

The procedure previously reported for the radiosynthesis of [123I]betaCIT was modified in order to improve both radiochemical yield and purity of betaCIT (2beta-carbomethoxy-3beta(4-iodophenyl) tropane) to be injected for SPECT (Single Photon Emission Computed Tomography) analysis imaging. The overall procedure, involving a HPLC purification step, results in quite good and reproducible yields of a highly purified tracer.

MeSH terms

  • Brain / diagnostic imaging*
  • Brain / metabolism*
  • Chromatography, High Pressure Liquid
  • Cocaine / analogs & derivatives
  • Cocaine / chemical synthesis*
  • Cocaine / pharmacokinetics
  • Dopamine / metabolism*
  • Humans
  • Iodine Radioisotopes*
  • Ligands
  • Radiopharmaceuticals / chemical synthesis*
  • Radiopharmaceuticals / pharmacokinetics
  • Serotonin / metabolism*
  • Tomography, Emission-Computed, Single-Photon / methods*

Substances

  • Iodine Radioisotopes
  • Ligands
  • Radiopharmaceuticals
  • Serotonin
  • 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane
  • Cocaine
  • Dopamine